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It is best suited for intravenous procedures because the concentration of electrolytes and water is equal to that in serum plasma (0.9%)

This is done because the vial is a vacuum, and you need to add an equal amount of air to regulate the pressure, making it easier to draw the medication into the syringe

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In part, this reflects excitation/inhibition balance and classical aminergic neuromodulatory tone in the brain, both of which are deranged by excess nitrogen and can ultimately cause excitotoxicity if nitrogen imbalances are not promptly addressed (Rangroo Thrane et al., 2013)